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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIRT1 All Species: 27.27
Human Site: S229 Identified Species: 50
UniProt: Q96EB6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96EB6 NP_001135970.1 747 81681 S229 Q I V I N I L S E P P K R K K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001087854 741 80936 S225 Q I V I N I L S E P P K R K K
Dog Lupus familis XP_546130 745 81496 S225 Q I V I N I L S E P P K R K K
Cat Felis silvestris
Mouse Mus musculus Q923E4 737 80353 S221 Q I V I N I L S E P P K R K K
Rat Rattus norvegicus Q5RJQ4 350 39301
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508324 480 51688 P44 I Y P G Q F Q P S L C H K F I
Chicken Gallus gallus NP_001004767 756 82614 S240 Q I V I N I L S E P P K R K K
Frog Xenopus laevis NP_001091195 710 78684 S205 Q I V I N I L S D P P K R K K
Zebra Danio Brachydanio rerio Q7ZVK3 379 42296
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477351 823 91818 N197 D Y L A H L L N E P K R R N K
Honey Bee Apis mellifera XP_395386 868 98678 S179 K I I I N M M S E P P R R Q K
Nematode Worm Caenorhab. elegans Q21921 607 68747 I171 D F R S K D G I Y A R L R S E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53685 503 57684 F67 K D K V T G K F I F P A I T K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.3 91.4 N.A. 85.1 23.4 N.A. 49.7 68.1 57.9 22.2 N.A. 37.2 39.9 31.3 N.A.
Protein Similarity: 100 N.A. 95.5 94.3 N.A. 90 33.3 N.A. 54.7 75.4 69.3 35 N.A. 52.2 55.9 47.5 N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 100 0 N.A. 0 100 93.3 0 N.A. 33.3 60 6.6 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 0 N.A. 6.6 100 100 0 N.A. 66.6 100 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 8 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 16 8 0 0 0 8 0 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 54 0 0 0 0 0 8 % E
% Phe: 0 8 0 0 0 8 0 8 0 8 0 0 0 8 0 % F
% Gly: 0 0 0 8 0 8 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 8 54 8 54 0 47 0 8 8 0 0 0 8 0 8 % I
% Lys: 16 0 8 0 8 0 8 0 0 0 8 47 8 47 70 % K
% Leu: 0 0 8 0 0 8 54 0 0 8 0 8 0 0 0 % L
% Met: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 54 0 0 8 0 0 0 0 0 8 0 % N
% Pro: 0 0 8 0 0 0 0 8 0 62 62 0 0 0 0 % P
% Gln: 47 0 0 0 8 0 8 0 0 0 0 0 0 8 0 % Q
% Arg: 0 0 8 0 0 0 0 0 0 0 8 16 70 0 0 % R
% Ser: 0 0 0 8 0 0 0 54 8 0 0 0 0 8 0 % S
% Thr: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % T
% Val: 0 0 47 8 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 16 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _